BioGlue Surgical Adhesive (BioGlue) is a two-component surgical adhesive composed of solutions of purified bovine serum albumin (BSA) and glutaraldehyde.

The solutions are dispensed by a controlled delivery system, composed of a double-chambered syringe, applicator tips, and optional applicator tip extenders.  Once dispensed, the adhesive solutions (in a predefined ratio) are mixed within the applicator tip where cross-linking begins.  The glutaraldehyde molecules covalently bond (cross-link) the BSA molecules to each other and, upon application, to the tissue proteins at the repair site, creating a flexible mechanical seal independent of the body's clotting mechanism.  The delivery device-mediated application is designed to provide reproducible mixing of the components in vitro.

BioGlue begins to polymerize within 20 to 30 seconds and reaches its bonding strength within 2 minutes.  BioGlue also adheres to synthetic graft materials via mechanical interlocks within the interstices of the graft matrix.  The BioGlue solutions component has a shelf life of 3 years if stored at 25 °C.